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Heppner, F L; Arrighi, I; Kalinke, U; Aguzzi, A (2001). Immunity against prions? Trends in Molecular Medicine, 7(11):477-479.

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Several recent reports indicate that antibodies directed against the cellular form of the prion protein, PrPC, might eliminate the transmissible agent of spongiform encephalopathies (the prion) from scrapie-infected cells in vitro, and that a humoral immune response could prevent scrapie pathogenesis in vivo. These findings suggest that immunotherapeutical intervention against prion diseases is not unattainable. Will vaccines and post-exposure strategies based on antibodies ever prove useful against scrapie, bovine spongiform encephalopathy (BSE), or Creutzfeldt–Jakob disease?


14 citations in Web of Science®
16 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Feb 2008 12:27
Last Modified:05 Apr 2016 12:21
Publisher DOI:10.1016/S1471-4914(01)02182-7
PubMed ID:11689311

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