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Several recent reports indicate that antibodies directed against the cellular form of the prion protein, PrPC, might eliminate the transmissible agent of spongiform encephalopathies (the prion) from scrapie-infected cells in vitro, and that a humoral immune response could prevent scrapie pathogenesis in vivo. These findings suggest that immunotherapeutical intervention against prion diseases is not unattainable. Will vaccines and post-exposure strategies based on antibodies ever prove useful against scrapie, bovine spongiform encephalopathy (BSE), or Creutzfeldt–Jakob disease?
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||11 Feb 2008 13:27|
|Last Modified:||27 Nov 2013 20:45|
|Citations:||Web of Science®. Times Cited: 14|
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