Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Glatzel, M; Klein, M A; Brandner, S; Aguzzi, A (2000). Prions: from neurografts to neuroinvasion. Archives of virology. Supplementum, 16(3):3-12.

Full text not available from this repository.


Spongiform encephalopathies are infectious neurodegenerative diseases caused by pathogens that seem to be devoid of any informational nucleic acids. Histopathologically, these diseases are characterized by spongiform degeneration of the central nervous system. Although the main pathological changes during the course of the disease occur in the brain, the infectious agent accumulates early in lymphoid tissue. The consecutive development of clinical disease depends on the presence of an intact immune system including mature B-cells and follicular dendritic cells. In this article we review the state of knowledge on the routes of neuroinvasion used by the infectious agent in order to gain access to the central nervous system upon entry into extracerebral sites.


7 citations in Web of Science®
10 citations in Scopus®
Google Scholar™

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Feb 2008 12:27
Last Modified:05 Apr 2016 12:21
Related URLs:http://www.knockoutscience.com/showabstract.php?pmid=11214933
PubMed ID:11214933

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page