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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-20171

Greber, U F; Puntener, D (2009). DNA-tumor virus entry-From plasma membrane to the nucleus. Seminars in Cell and Developmental Biology, 20(5):631-642.

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Abstract

DNA-tumor viruses comprise enveloped and non-enveloped agents that cause malignancies in a large variety of cell types and tissues by interfering with cell cycle control and immortalization. Those DNA-tumor viruses that replicate in the nucleus use cellular mechanisms to transport their genome and newly synthesized viral proteins into the nucleus. This requires cytoplasmic transport and nuclear import of their genome. Agents that employ this strategy include adenoviruses, hepadnaviruses, herpesviruses, and likely also papillomaviruses, and polyomaviruses, but not poxviruses which replicate in the cytoplasm. Here, we discuss how DNA-tumor viruses enter cells, take advantage of cytoplasmic transport, and import their DNA genome through the nuclear pore complex into the nucleus. Remarkably, nuclear import of incoming genomes does not necessarily follow the same pathways used by the structural proteins of the viruses during the replication and assembly phases of the viral life cycle. Understanding the mechanisms of DNA nuclear import can identify new pathways of cell regulation and anti-viral therapies.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Uncontrolled Keywords:nucleocytoplasmic transport, nuclear pore complex, cytoplasmic transport, cell transformation, virus entry
Language:English
Date:July 2009
Deposited On:18 Aug 2009 14:31
Last Modified:27 Nov 2013 20:39
Publisher:Elsevier
ISSN:1084-9521
Publisher DOI:10.1016/j.semcdb.2009.03.014
PubMed ID:19588547
Citations:Web of Science®. Times Cited: 8
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Scopus®. Citation Count: 15

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