Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-20226
Bagnall, M W; Zingg, B; Sakatos, A; Moghadam, S H; Zeilhofer, H U; Lac, S (2009). Glycinergic projection neurons of the cerebellum. Journal of Neuroscience, 29(32):10104-10110.
The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to the inferior olive. Here we use transgenic mice selectively expressing green fluorescent protein in glycinergic neurons to demonstrate that many premotor output neurons in the medial cerebellar (fastigial) nuclei are in fact glycinergic, not glutamatergic as previously thought. These neurons exhibit similar firing properties as neighboring glutamatergic neurons and receive direct input from both Purkinje cells and excitatory fibers. Glycinergic fastigial neurons make functional projections to vestibular and reticular neurons in the ipsilateral brainstem, whereas their glutamatergic counterparts project contralaterally. Together, these data suggest that the cerebellum can influence motor outputs via two distinct and complementary pathways.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Date:||12 August 2009|
|Deposited On:||18 Aug 2009 07:22|
|Last Modified:||27 Nov 2013 18:53|
|Publisher:||Society for Neuroscience|
|Additional Information:||Holder of copyright: The Society for Neuroscience|
|Citations:||Web of Science®. Times Cited: 31|
Scopus®. Citation Count: 35
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