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Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought


Pluta, R M; Hansen-Schwartz, J; Dreier, J; Vajkoczy, P; Macdonald, R L; Nishizawa, S; Kasuya, H; Wellmann, G; Keller, E; Zauner, A; Dorsch, N; Clark, J; Ono, S; Kiris, T; Leroux, P; Zhang, J H (2009). Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought. Neurological Research, 31(2):151-158.

Abstract

Objective: Delayed cerebral vasospasm has long been recog-nized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.
Method: Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.
Result: It will focus on current accepted mechanisms and on new frontiers in vasospasm research.
Conclusion: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.

Objective: Delayed cerebral vasospasm has long been recog-nized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.
Method: Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.
Result: It will focus on current accepted mechanisms and on new frontiers in vasospasm research.
Conclusion: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.

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152 citations in Web of Science®
177 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2009
Deposited On:25 Aug 2009 08:59
Last Modified:05 Apr 2016 13:19
Publisher:Maney Publishing
ISSN:0161-6412
Publisher DOI:10.1179/174313209X393564
PubMed ID:19298755
Permanent URL: http://doi.org/10.5167/uzh-20337

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