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Up-down asymmetry of cerebellar activation during vertical pursuit eye movements


Glasauer, S; Stephan, T; Kalla, R; Marti, S; Straumann, D (2009). Up-down asymmetry of cerebellar activation during vertical pursuit eye movements. Cerebellum, 8(3):385-388.

Abstract

Animal experiments have demonstrated that the vast majority of vertical gaze-velocity Purkinje cells in the cerebellar floccular lobe, whose firing rate is modulated during vertical smooth pursuit eye movements, show a preference for downward pursuit. Here we validate the functional vertical asymmetry of the cerebellar flocculus in humans using functional magnetic resonance imaging by demonstrating a significantly higher activation of the floccular lobe for downward than for upward pursuit. The findings corroborate our recent hypothesis on the pathogenesis of cerebellar downbeat nystagmus.

Animal experiments have demonstrated that the vast majority of vertical gaze-velocity Purkinje cells in the cerebellar floccular lobe, whose firing rate is modulated during vertical smooth pursuit eye movements, show a preference for downward pursuit. Here we validate the functional vertical asymmetry of the cerebellar flocculus in humans using functional magnetic resonance imaging by demonstrating a significantly higher activation of the floccular lobe for downward than for upward pursuit. The findings corroborate our recent hypothesis on the pathogenesis of cerebellar downbeat nystagmus.

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10 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:03 Sep 2009 07:27
Last Modified:05 Apr 2016 13:20
Publisher:Springer
ISSN:1473-4222
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:https://doi.org/10.1007/s12311-009-0109-5
PubMed ID:19415407
Permanent URL: https://doi.org/10.5167/uzh-20546

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