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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-20656

Althoff, F; Viktorinová, I; Kastl, J; Lehner, C F (2009). Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions. Developmental Biology, 333(2):263-272.

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Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expressing Cyclin J versions with N- or C-terminal GFP extensions, we demonstrate that it is expressed exclusively in the germline. After low level expression in all nuclei within the germarium, it gets highly enriched in the germinal vesicle within the oocyte until stage 12 of oogenesis, followed by disappearance after germinal vesicle breakdown before the first meiotic division. Surprisingly, Cyclin J is not required for female fertility. Chromosome segregation during female meiosis, as well as the rapid early embryonic cell cycles after fertilization, occurs normally in the complete absence of Cyclin J. Cyclin J with EGFP fused at either N- or C-terminus binds to Cdk1 and not to Cdk2. However, in contrast to the other known Cdk1 partners, the A- and B-type cyclins, Cyclin J is not degraded during mitosis.


2 citations in Web of Science®
2 citations in Scopus®
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156 downloads since deposited on 18 Sep 2009
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:15 September 2009
Deposited On:18 Sep 2009 12:51
Last Modified:05 Apr 2016 13:20
Publisher DOI:10.1016/j.ydbio.2009.06.042
PubMed ID:19591820

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