Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-20747

Gwehenberger, B; Rist, L; Huch, R; von Mandach, U (2004). Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. European Journal of Obstetrics and Gynecology and Reproductive Biology, 113(2):164-171.

View at publisher


To characterise the phytotherapeutic tocolytic Bryophyllum pinnatum in vitro versus the conventional betamimetic, fenoterol, in human myometrium. STUDY DESIGN: Contractility (endpoints: area under the curve (AUC), amplitude and frequency of isometric force development) was measured in strips of term myometrium biopsied at caesarean section in 14 women and exposed to increasing concentrations of B. pinnatum versus +/- oxytocin 1 U/l. RESULTS: Inhibition of spontaneous contraction by B. pinnatum was concentration-dependent: 16% at maximum concentration (10(4) mg/l), or 53% that with fenoterol 5 x 10(-8)mol/l. B. pinnatum increased contraction frequency by 91% at constant amplitude and inhibited oxytocin-stimulated contractions by 20% (AUC) at constant amplitude with slightly decreased frequency. Fenoterol decreased contraction AUC by 50% with a significant decrease in frequency. CONCLUSION: Our in vitro data confirm the tocolytic activity of B. pinnatum observed in alternative medicine centres and may justify further clinical studies.


15 citations in Web of Science®
19 citations in Scopus®
Google Scholar™



107 downloads since deposited on 25 Sep 2009
17 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Deposited On:25 Sep 2009 14:26
Last Modified:05 Apr 2016 13:21
Publisher DOI:10.1016/S0301-2115(03)00370-1
Other Identification Number:15063954

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page