Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-21085
Knuesel, I; Nyffeler, M; Mormède, C; Muhia, M; Meyer, U; Pietropaolo, S; Yee, B K; Pryce, C R; LaFerla, F M; Marighetto, A; Feldon, J (2009). Age-related accumulation of Reelin in amyloid-like deposits. Neurobiology of Aging, 30(5):697-716.
- Registered users only
View at publisher
Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia. However, limited information is available on the effect of age, the major risk factor of AD, on Reelin expression. Here, we report that normal aging in rodents and primates is accompanied by accumulation of Reelin-enriched proteinous aggregates in the hippocampal formation that are related to the loss of Reelin-expressing neurons. Both phenomena are associated with age-related memory impairments in wild-type mice. We provide evidence that normal aging involves loss of Reelin neurons, reduced production and elimination of the extracellular deposits, whereas a prenatal immune challenge or the expression of AD-causing gene products, result in earlier, higher, and more persistent levels of Reelin-positive deposits. These aggregates co-localize with non-fibrillary amyloid-plaques, potentially representing oligomeric Abeta species. Our findings suggest that elevated Reelin plaque load creates a precursor condition for senile plaque deposition and may represent a critical risk factor for sporadic AD.
141 downloads since deposited on 06 Oct 2009
38 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||06 Oct 2009 12:34|
|Last Modified:||27 Nov 2013 20:47|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page