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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-21085

Knuesel, I; Nyffeler, M; Mormède, C; Muhia, M; Meyer, U; Pietropaolo, S; Yee, B K; Pryce, C R; LaFerla, F M; Marighetto, A; Feldon, J (2009). Age-related accumulation of Reelin in amyloid-like deposits. Neurobiology of Aging, 30(5):697-716.

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Abstract

Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia. However, limited information is available on the effect of age, the major risk factor of AD, on Reelin expression. Here, we report that normal aging in rodents and primates is accompanied by accumulation of Reelin-enriched proteinous aggregates in the hippocampal formation that are related to the loss of Reelin-expressing neurons. Both phenomena are associated with age-related memory impairments in wild-type mice. We provide evidence that normal aging involves loss of Reelin neurons, reduced production and elimination of the extracellular deposits, whereas a prenatal immune challenge or the expression of AD-causing gene products, result in earlier, higher, and more persistent levels of Reelin-positive deposits. These aggregates co-localize with non-fibrillary amyloid-plaques, potentially representing oligomeric Abeta species. Our findings suggest that elevated Reelin plaque load creates a precursor condition for senile plaque deposition and may represent a critical risk factor for sporadic AD.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:May 2009
Deposited On:06 Oct 2009 12:34
Last Modified:27 Nov 2013 20:47
Publisher:Elsevier
ISSN:0197-4580
Publisher DOI:10.1016/j.neurobiolaging.2007.08.011
PubMed ID:17904250
Citations:Web of Science®. Times Cited: 34
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Scopus®. Citation Count: 32

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