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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-21168

Willi, R; Aloy, E M; Yee, B K; Feldon, J; Schwab, M E (2009). Behavioral characterization of mice lacking the neurite outgrowth inhibitor Nogo-A. Genes, Brain and Behavior, 8(2):181-192.

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Abstract

The membrane protein Nogo-A inhibits neurite outgrowth and regeneration in the injured central nervous system, primarily because of its expression in oligodendrocytes. Hence, deletion of Nogo-A enhances regeneration following spinal cord injury. Yet, the effects of Nogo-A deletion on general behavior and cognition have not been explored. The possibility of potential novel functions of Nogo-A beyond growth inhibition is strongly suggested by the presence of subpopulations of neurons also expressing Nogo-A - not only during development but also in adulthood. We evaluated here Nogo-A(-/-) mice in a series of general basic behavioral assays as well as functional analyses related to brain regions with notable expression levels of Nogo-A. The SHIRPA protocol did not show any major basic behavioral changes in Nogo-A(-/-) mice. Anxiety-related behavior, pain sensitivity, startle reactivity, spatial learning, and associative learning also appeared indistinguishable between Nogo-A(-/-) and control Nogo-A(+/+) mice. However, motor co-ordination and balance were enhanced in Nogo-A(-/-) mice. Spontaneous locomotor activity was also elevated in Nogo-A(-/-) mice, but this was specifically observed in the dark (active) phase of the circadian cycle. Enhanced locomotor reaction to systemic amphetamine in Nogo-A(-/-) mice further pointed to an altered dopaminergic tone in these mice. The present study is the first behavioral characterization of mice lacking Nogo-A and provides significant insights into the potential behavioral relevance of Nogo-A in the modulation of dopaminergic and motor functions.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:12 Oct 2009 11:49
Last Modified:28 Nov 2013 01:11
Publisher:Wiley-Blackwell
ISSN:1601-183X
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:10.1111/j.1601-183X.2008.00460.x
PubMed ID:19077178
Citations:Web of Science®. Times Cited: 17
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Scopus®. Citation Count: 17

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