Böni, J; Pyra, H; Gebhardt, M; Perrin, L; Bürgisser, P; Matter, L; Fierz, W; Erb, P; Piffaretti, J C; Minder, E; Grob, P; Burckhardt, J J; Zwahlen, M; Schüpbach, J (1999). High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland. JAIDS Journal of Acquired Immune Deficiency Syndromes, 22(2):174-179.
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HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heteroduplex mobility assay. All amplicons not identified as B were sequenced. From November 1996 to February 1998, 206 samples were analyzed. Main transmission risks were unprotected heterosexual (55.7%) or homosexual (27.1%) sexual contact or intravenous drug use (12.9%). Subtype B dominated in patients of Swiss, other European, American, or Asian citizenship; particularly high frequencies were found in homosexuals (97%) and drug users (94%). Non-B subtypes including A, C, D, E, F, G, H, a possible B/F recombinant, and a sequence related to J were present in 28.2% (95% confidence interval [CI], 22.9%-35.0%). Non-B were frequent in African citizens (95%), heterosexually infected individuals (44%), and women (43%). Heterosexually infected Swiss males harbored non-B strains in 18% and females in 33%. The results document a change in the epidemiology of newly diagnosed HIV-1 infections in Switzerland: predominance of heterosexual transmission and a high frequency of non-B subtypes.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > Institute of Medical Virology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||01 October 1999|
|Deposited On:||11 Feb 2008 13:28|
|Last Modified:||27 Nov 2013 20:26|
|Publisher:||Lippincott Wiliams & Wilkins|
|Citations:||Web of Science®. Times cited: 65|
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