Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Seemayer, C A; Böni, J; Steiger, J; Schüpbach, J; Mihatsch, M J (2006). No indication for activation of exogenous retroviruses in patients with renal allograft rejection. Clinical Nephrology, 65(5):324-327.

Full text not available from this repository.

Abstract

AIM: Reactivation of latent BK virus in kidney-transplanted patients results in severe graft dysfunction. The role of retroviruses infecting also latently target cells is not investigated so far in this setting. We determined the presence or induction of retroviruses in sera of immunosuppressed patients with renal allografts at the timepoint of organ rejection or ongoing polyomavirus nephropathy. PATIENTS AND METHODS: Sera of patients with acute kidney rejection or polyomavirus nephropathy (n=25) and controls (n=8) were tested for reverse transcriptase activity by the ultrasensitive product enhanced reverse transcriptase (PERT) assay. In parallel, kidney biopsies were investigated for histological signs of kidney rejection or polyomavirus nephropathy confirmed by either immunofluorescence or immunohistochemistry. RESULTS: None of the investigated sera, specifically those of patients with ongoing BK virus nephropathy, indicated reverse transcriptase activity. CONCLUSION: Our results do not support the idea of the induction of known or unknown retroviruses in patients with kidney transplantation, even under highly immunosuppressive therapies.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:01 May 2006
Deposited On:11 Feb 2008 13:28
Last Modified:27 Nov 2013 20:36
Publisher:Dustri
ISSN:0301-0430
Related URLs:http://www.dustri-verlag.de/clinnephrol/index_journal.htm
PubMed ID:16724652
Citations:Web of Science®
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page