## Abstract

We consider a positively graded noetherian domain $R = \bigoplus_{n \in \BN_{0}} R_{n}$ for which $R_{0}$ is essentially of finite type over a perfect field $K$ of positive characteristic and we assume that the generic fibre of the natural morphism $\pi : Y = \Proj(R) \to Y_{0} = \Spec(R_{0})$ is geometrically connected, geometrically normal and of dimension $> 1$. Then we give bounds on the "ranks" of the $n$-th homogeneous part $H^{2}_{R_{+}} (R)_{n}$ of the second local cohomology module of $R$ with respect to $R_{+} := \bigoplus_{m > 0} R_{m}$ for $n < 0$. If $Y$ is in addition normal, we shall see that the $R_{0}$-modules $H^{2}_{R_{+}} (R)_{n}$ are torsion-free for all $n < 0$ and in this case our bounds on the ranks furnish a vanishing result. From these results we get bounds on the first cohomology of ample invertible sheaves in positive characteristic.