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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-221

Makhankov, Y V; Rinner, O; Neuhauss, S C F (2004). An inexpensive device for non-invasive electroretinography in small aquatic vertebrates. Journal of Neuroscience Methods, 135(1-2):205-210.

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Abstract

Electroretinographic (ERG) method records a sum field potential of the retina in response to light. It mainly arises in the outer retina and is used as a non-invasive measure in both animal experiments and the clinic. Since it is a comprehensive method to assess outer retinal function, it is becoming increasingly useful in genetic studies of vision. Here we present a simple in-house built setup to measure ERGs of aquatic vertebrates. We have used this setup to efficiently and reliably measure intact larvae of zebrafish (Danio rerio), Medaka fish (Oryzias latipes), and Xenopus laevis tadpoles. By slight modification of the setup, we were also able to measure adult zebrafish and Medaka, demonstrating the general versatility of the setup. We picked these organisms since they are increasingly used to study visual function with genetic means. This setup is easily built and will be particularly useful for laboratories setting up ERG measurements as a complement to their genetic studies.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:30 May 2004
Deposited On:11 Feb 2008 12:13
Last Modified:27 Nov 2013 19:44
Publisher:Elsevier
ISSN:0165-0270
Publisher DOI:10.1016/j.jneumeth.2003.12.015
PubMed ID:15020104
Citations:Web of Science®. Times Cited: 20
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Scopus®. Citation Count: 24

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