Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-228
Neuhauss, S C F; Solnica-Krezel, L; Schier, A F; Zwartkruis, F J T; Stemple, D L; Malicki, J; Abdelilah, S; Stainier, D Y; Driever, W (1996). Mutations affecting craniofacial development in zebrafish. Development, 123:357-367.
In a large-scale screen for mutations affecting embryogenesis in zebrafish, we identified 48 mutations in 34 genetic loci specifically affecting craniofacial development. Mutants were analyzed for abnormalities in the cartilaginous head skeleton. Further, the expression of marker genes was studied to investigate potential abnormalities in mutant rhombencephalon, neural crest, and pharyngeal endoderm. The results suggest that the identified mutations affect three distinct aspects of craniofacial development. In one group, mutations affect the overall pattern of the craniofacial skeleton, suggesting that the genes are involved in the specification of these elements. Another large group of mutations affects differentiation and morphogenesis of cartilage, and may provide insight into the genetic control of chondrogenesis. The last group of mutations leads to the abnormal arrangement of skeletal elements and may uncover important tissue-tissue interactions underlying jaw development.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||01 December 1996|
|Deposited On:||11 Feb 2008 13:13|
|Last Modified:||27 Nov 2013 20:42|
|Publisher:||Company of Biologists|
|Citations:||Web of Science®. Times Cited: 129|
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