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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-228

Neuhauss, S C F; Solnica-Krezel, L; Schier, A F; Zwartkruis, F J T; Stemple, D L; Malicki, J; Abdelilah, S; Stainier, D Y; Driever, W (1996). Mutations affecting craniofacial development in zebrafish. Development, 123:357-367.

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Abstract

In a large-scale screen for mutations affecting embryogenesis in zebrafish, we identified 48 mutations in 34 genetic loci specifically affecting craniofacial development. Mutants were analyzed for abnormalities in the cartilaginous head skeleton. Further, the expression of marker genes was studied to investigate potential abnormalities in mutant rhombencephalon, neural crest, and pharyngeal endoderm. The results suggest that the identified mutations affect three distinct aspects of craniofacial development. In one group, mutations affect the overall pattern of the craniofacial skeleton, suggesting that the genes are involved in the specification of these elements. Another large group of mutations affects differentiation and morphogenesis of cartilage, and may provide insight into the genetic control of chondrogenesis. The last group of mutations leads to the abnormal arrangement of skeletal elements and may uncover important tissue-tissue interactions underlying jaw development.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:01 December 1996
Deposited On:11 Feb 2008 13:13
Last Modified:27 Nov 2013 20:42
Publisher:Company of Biologists
ISSN:0950-1991
PubMed ID:9007255
Citations:Web of Science®. Times Cited: 132
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