Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2299

Handschin, C; Kobayashi, Y M; Chin, S; Seale, P; Campbell, K P; Spiegelman, B M (2007). PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes and Development, 21(7):770-783.

[img]
Preview
Accepted Version
PDF
488kB

View at publisher

Abstract

The coactivator PGC-1alpha mediates key responses of skeletal muscle to motor nerve activity. We show here that neuregulin-stimulated phosphorylation of PGC-1alpha and GA-binding protein (GABP) allows recruitment of PGC-1alpha to the GABP complex and enhances transcription of a broad neuromuscular junction gene program. Since a subset of genes controlled by PGC-1alpha and GABP is dysregulated in Duchenne muscular dystrophy (DMD), we examined the effects of transgenic PGC-1alpha in muscle of mdx mice. These animals show improvement in parameters characteristic of DMD, including muscle histology, running performance, and plasma creatine kinase levels. Thus, control of PGC-1alpha levels in skeletal muscle could represent a novel avenue to prevent or treat DMD.

Citations

122 citations in Web of Science®
122 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

44 downloads since deposited on 18 Mar 2008
7 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Language:English
Date:2007
Deposited On:18 Mar 2008 10:04
Last Modified:27 Nov 2013 18:24
Publisher:Cold Spring Harbor Laboratory Press
ISSN:0890-9369
Publisher DOI:10.1101/gad.1525107
PubMed ID:17403779

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page