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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23240

Fuchs, B; Hoekzema, N; Larson, D R; Inwards, C Y; Sim, F H (2009). Osteosarcoma of the pelvis: outcome analysis of surgical treatment. Clinical Orthopaedics and Related Research, 467(2):510-518.

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Abstract

Risk factors to explain the poor survival of patients with osteosarcoma of the pelvis are poorly understood. Therefore, we attempted to identify factors affecting survival and development of local recurrence and metastasis. We retrospectively reviewed 43 patients who had high-grade pelvic tumors and were treated surgically. Twenty lesions were chondroblastic, 10 fibroblastic, 11 osteoblastic, and one each was giant cell-rich and small cell osteosarcomas. At a median of 3.5 years (range, 0.3-21 years) postoperatively, 13 patients were alive with no evidence of disease. The overall and disease-free 5-year survival rates were 38% and 29%, respectively, at 5 years. Anatomic location, tumor size, and margin predicted survival. Fifteen patients (35%) had local recurrence. The 5-year cumulative incidence of recurrence with death as a competing risk factor was 34%. Location in the ilium and size of the tumor predicted local recurrence. Twenty-one (49%) of 43 patients had metastases develop. The cumulative incidence of metastasis with death as a competing risk factor was 48% at 5 years. Six patients who presented with metastasis had a worse survival than patients who had no evidence of metastasis at presentation (2-year survival, 33% versus 76%). If distant metastasis is diagnosed subsequent to primary treatment, aggressive therapy may be justified. Level of Evidence: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:19 Oct 2009 11:00
Last Modified:27 Nov 2013 17:25
Publisher:Springer
ISSN:0009-921X
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s11999-008-0495-x
PubMed ID:18855090
Citations:Web of Science®. Times Cited: 21
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