Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23365
Bogdanova, A; Berenbrink, M; Nikinmaa, M (2009). Oxygen-dependent ion transport in erythrocytes. Acta Physiologica, 195(3):305-319.
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The present contribution reviews current knowledge of apparently oxygen-dependent ion transport in erythrocytes and presents modern hypotheses on their regulatory mechanisms and physiological roles. In addition to molecular oxygen as such, reactive oxygen species, nitric oxide, carbon monoxide, regional variations of cellular ATP and hydrogen sulphide may play a role in the regulation of transport, provided that they are affected by oxygen tension. It appears that the transporter molecules themselves do not have direct oxygen sensors. Thus, the oxygen level must be sensed elsewhere, and the effect transduced to the transporter. The possible pathways involved in the regulation of transport, including haemoglobin as a sensor, and phosphorylation/dephosphorylation reactions both in the transporter and its upstream effectors, are discussed.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||21 Oct 2009 07:51|
|Last Modified:||27 Nov 2013 23:44|
|Additional Information:||The definitive version is available at www.blackwell-synergy.com|
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