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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-234

Greber, U F (2002). Signalling in viral entry. Cellular and Molecular Life Sciences, 59(4):608-626.



Viral infections are serious battles between pathogens and hosts. They can result in cell death, elimination of the virus or latent infection keeping both cells and pathogens alive. The outcome of an infection is often determined by cell signalling. Viruses deliver genomes and proteins with signalling potential into target cells and thereby alter the metabolism of the host. Virus interactions with cell surface receptors can elicit two types of signals, conformational changes of viral particles, and intracellular signals triggering specific cellular reactions. Responses by cells include stimulation of innate and adaptive immunity, growth, proliferation, survival and apoptosis. In addition, virus-activated cell signalling boosts viral entry and gene delivery, as recently shon for adenoviruses and adeno-associated viruses. This review illustrates that multiple activation of host cells during viral entry profoundly impacts the elaborate relationship between hosts and viral pathogens.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Date:1 April 2002
Deposited On:11 Feb 2008 12:13
Last Modified:27 Nov 2013 16:38
Publisher DOI:10.1007/s00018-002-8453-3
Related URLs:http://www.springerlink.com/content/08d43w9u9696j2c3/
PubMed ID:12022470
Citations:Web of Science®. Times Cited: 110
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Scopus®. Citation Count: 105

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