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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23459

Shete, S; Hosking, F J; Robertson, L B; Dobbins, S E; Sanson, M; Malmer, B; Simon, M; Marie, Y; Boisselier, B; Delattre, J Y; Hoang-Xuan, K; El Hallani, S; Idbaih, A; Zelenika, D; Andersson, U; Henriksson, R; Bergenheim, A T; Feychting, M; Lönn, S; Ahlbom, A; Schramm, J; Linnebank, M; Hemminki, K; Kumar, R; Hepworth, S J; Price, A; Armstrong, G; Liu, Y; Gu, X; Yu, R; Lau, C; Schoemaker, M; Muir, K; Swerdlow, A; Lathrop, M; Bondy, M; Houlston, R S (2009). Genome-wide association study identifies five susceptibility loci for glioma. Nature Genetics, 41(8):899-904.

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To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Date:August 2009
Deposited On:02 Nov 2009 09:21
Last Modified:27 Nov 2013 23:01
Publisher:Nature Publishing Group
Publisher DOI:10.1038/ng.407
PubMed ID:19578367

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