Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23463
Klotz, L; Farkas, M; Bain, N; Keskitalo, S; Semmler, A; Ineichen, B; Jelcic, J; Klockgether, T; Kösch, H; Weller, M; Linnebank, M (2010). The variant methylenetetrahydrofolate reductase c.1298A > C (p.E429A) is associated with multiple sclerosis in a German case-control study. Neuroscience Letters, 468(3):183-185.
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Multiple Sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the central nervous system. We investigated the association of two missense variants of the MTHFR gene, i.e. MTHFR c.677C>T (p.A222V) and c.1298A>C (p.E429A), in 138 patients with clinically definite multiple sclerosis (MS) of relapsing remitting course and 138 age- and gender-matched healthy controls. No significant differences were found in the frequency of the MTHFR c.677C>T polymorphism between MS patients and healthy controls. However, the genotype frequencies of the missense variant MTHFR c.1298A>C were significantly different between patients (AA/AC/CC: 0.34/0.55/0.11) and controls (0.52/0.36/0.12; Pearson's chi(2)=11.1; p=0.004). These results suggest that homozygosity for the A allele of MTHFR c.1298A>C may be protective against the incidence of MS. If confirmed in an independent study sample, the underlying mechanisms should be investigated, which may lead to novel insights in biochemical factors influencing the aetiology and pathophysiology of MS.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology|
|DDC:||610 Medicine & health|
|Date:||14 January 2010|
|Deposited On:||02 Nov 2009 17:49|
|Last Modified:||27 Nov 2013 19:45|
|Citations:||Web of Science®. Times Cited: 4|
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