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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23472

Sarnthein, J; Andersson, M; Zimmermann, M; Zumsteg, D (2009). High test-retest reliability of checkerboard reversal visual evoked potentials (VEP) over 8 months. Clinical Neurophysiology, 120(10):1835-1840.

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OBJECTIVE: The inter-individual variation in the shape of a visual evoked potential (VEP) is large even for simple stimuli. We compared the inter-individual variation in VEP waveform to the intra-individual stability. METHODS: We recorded VEP with checkerboard stimulation in 10 women aged 19-29years in two sessions. We determined the latencies and the peak-to-peak amplitude of N75 and P100. As a new approach in VEP research, we regressed VEP waveforms pairwise onto each other and calculated a t-value between all sessions. The maximal t-value was taken to indicate recognition for all 19 comparisons performed with one session. The recognition rate was cross-validated in a generalized linear regression model (GLM). RESULTS: The number of sessions correctly matched to the correct subject was 19 of 20 (true positives) leading to a sensitivity of 95.0% with confidence interval [75.1% 99.9%] for the method. The number of true negatives was 359 of 360 leading to a specificity of 99.7% [98.5% 100.0%]. CONCLUSIONS: The VEP waveform shows high intra-individual stability compared to the inter-individual variation in healthy women. SIGNIFICANCE: With a new statistical approach the effect of external factors on the VEP waveform can now be contrasted against the normal variability over time in longitudinal studies.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:October 2009
Deposited On:02 Nov 2009 09:37
Last Modified:05 Apr 2016 13:31
Publisher DOI:10.1016/j.clinph.2009.08.014
PubMed ID:19762276

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