UZH-Logo

High test-retest reliability of checkerboard reversal visual evoked potentials (VEP) over 8 months


Sarnthein, J; Andersson, M; Zimmermann, M; Zumsteg, D (2009). High test-retest reliability of checkerboard reversal visual evoked potentials (VEP) over 8 months. Clinical Neurophysiology, 120(10):1835-1840.

Abstract

OBJECTIVE: The inter-individual variation in the shape of a visual evoked potential (VEP) is large even for simple stimuli. We compared the inter-individual variation in VEP waveform to the intra-individual stability. METHODS: We recorded VEP with checkerboard stimulation in 10 women aged 19-29years in two sessions. We determined the latencies and the peak-to-peak amplitude of N75 and P100. As a new approach in VEP research, we regressed VEP waveforms pairwise onto each other and calculated a t-value between all sessions. The maximal t-value was taken to indicate recognition for all 19 comparisons performed with one session. The recognition rate was cross-validated in a generalized linear regression model (GLM). RESULTS: The number of sessions correctly matched to the correct subject was 19 of 20 (true positives) leading to a sensitivity of 95.0% with confidence interval [75.1% 99.9%] for the method. The number of true negatives was 359 of 360 leading to a specificity of 99.7% [98.5% 100.0%]. CONCLUSIONS: The VEP waveform shows high intra-individual stability compared to the inter-individual variation in healthy women. SIGNIFICANCE: With a new statistical approach the effect of external factors on the VEP waveform can now be contrasted against the normal variability over time in longitudinal studies.

OBJECTIVE: The inter-individual variation in the shape of a visual evoked potential (VEP) is large even for simple stimuli. We compared the inter-individual variation in VEP waveform to the intra-individual stability. METHODS: We recorded VEP with checkerboard stimulation in 10 women aged 19-29years in two sessions. We determined the latencies and the peak-to-peak amplitude of N75 and P100. As a new approach in VEP research, we regressed VEP waveforms pairwise onto each other and calculated a t-value between all sessions. The maximal t-value was taken to indicate recognition for all 19 comparisons performed with one session. The recognition rate was cross-validated in a generalized linear regression model (GLM). RESULTS: The number of sessions correctly matched to the correct subject was 19 of 20 (true positives) leading to a sensitivity of 95.0% with confidence interval [75.1% 99.9%] for the method. The number of true negatives was 359 of 360 leading to a specificity of 99.7% [98.5% 100.0%]. CONCLUSIONS: The VEP waveform shows high intra-individual stability compared to the inter-individual variation in healthy women. SIGNIFICANCE: With a new statistical approach the effect of external factors on the VEP waveform can now be contrasted against the normal variability over time in longitudinal studies.

Citations

10 citations in Web of Science®
10 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

6 downloads since deposited on 02 Nov 2009
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:October 2009
Deposited On:02 Nov 2009 09:37
Last Modified:05 Apr 2016 13:31
Publisher:Elsevier
ISSN:1388-2457
Publisher DOI:10.1016/j.clinph.2009.08.014
PubMed ID:19762276
Permanent URL: http://doi.org/10.5167/uzh-23472

Download

[img]Filetype: PDF - Registered users only
Size: 1MB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations