Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23524
Centanin, L; Gorr, T A; Wappner, P (2010). Tracheal remodelling in response to hypoxia. Journal of Insect Physiology, 56(5):447-454.
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The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
|DDC:||570 Life sciences; biology
610 Medicine & health
|Date:||10 May 2010|
|Deposited On:||02 Nov 2009 11:51|
|Last Modified:||27 Nov 2013 18:37|
|Citations:||Web of Science®. Times Cited: 21|
Scopus®. Citation Count: 17
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