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Structures of Micelle-Bound Selected Insect Neuropeptides and Analogues: Implications for Receptor Selection


Zdobinsky, T; Scherkenbeck, J; Zerbe, O; Antonicek, H; Chen, H (2009). Structures of Micelle-Bound Selected Insect Neuropeptides and Analogues: Implications for Receptor Selection. ChemBioChem, 10(16):2644-2653.

Abstract

Neuropeptides control essential physiological processes in insects such as water balance and muscle activity. Due to their metabolic instability and adverse physiochemical properties, insect neuropeptides are unsuited for a direct application in plant protection. As a first approximation towards the biologically active conformation, the structures of selected neuropeptides from economically important pest insects were determined by NMR spectroscopy and fluorescence measurements in a membrane-mimicking environment. A receptor binding model is suggested for the helicokinins and discussed in connection with biological activities and membrane-bound conformations of linear and cyclic analogues.

Neuropeptides control essential physiological processes in insects such as water balance and muscle activity. Due to their metabolic instability and adverse physiochemical properties, insect neuropeptides are unsuited for a direct application in plant protection. As a first approximation towards the biologically active conformation, the structures of selected neuropeptides from economically important pest insects were determined by NMR spectroscopy and fluorescence measurements in a membrane-mimicking environment. A receptor binding model is suggested for the helicokinins and discussed in connection with biological activities and membrane-bound conformations of linear and cyclic analogues.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:insect neuropeptides NMR micelles
Language:English
Date:2009
Deposited On:12 Nov 2009 15:03
Last Modified:05 Apr 2016 13:31
Publisher:Wiley VCH
ISSN:1439-4227
Publisher DOI:https://doi.org/10.1002/cbic.200900450
Permanent URL: https://doi.org/10.5167/uzh-23553

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