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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-236

Solnica-Krezel, L; Stemple, D L; Mountcastle-Shah, E; Rangini, Z; Neuhauss, S C F; Malicki, J; Schier, A F; Stainier, D Y; Zwartkruis, F J T; Abdelilah, S; Driever, W (1996). Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development, 123:67-80.

Published Version


One of the major challenges of developmental biology is understanding the inductive and morphogenetic processes that shape the vertebrate embryo. In a large-scale genetic screen for zygotic effect, embryonic lethal mutations in zebrafish we have identified 25 mutations that affect specification of cell fates and/or cellular rearrangements during gastrulation. These mutations define at least 14 complementation groups, four of which correspond to previously identified genes. Phenotypic analysis of the ten novel loci revealed three groups of mutations causing distinct effects on cell fates in the gastrula. One group comprises mutations that lead to deficiencies in dorsal mesodermal fates and affect central nervous system patterning. Mutations from the second group affect formation of ventroposterior embryonic structures. We suggest that mutations in these two groups identify genes necessary for the formation, maintenance or function of the dorsal organizer and the ventral signaling pathway, respectively. Mutations in the third group affect primarily cellular rearrangements during gastrulation and have complex effects on cell fates in the embryo. This group, and to some extent mutations from the first two groups, affect the major morphogenetic processes, epiboly, convergence and extension, and tail morphogenesis. These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates.


210 citations in Web of Science®
226 citations in Scopus®
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180 downloads since deposited on 11 Feb 2008
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:1 December 1996
Deposited On:11 Feb 2008 12:13
Last Modified:05 Apr 2016 12:13
Publisher:Company of Biologists
PubMed ID:9007230

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