Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23695
Grathwohl, S A; Kälin, R E; Bolmont, T; Prokop, S; Winkelmann, G; Kaeser, S A; Odenthal, J; Radde, R; Eldh, T; Gandy, S; Aguzzi, A; Staufenbiel, M; Mathews, P M; Wolburg, H; Heppner, F L; Jucker, M (2009). Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience, 12(11):1361-1363.
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In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||09 Nov 2009 17:12|
|Last Modified:||28 Nov 2013 00:15|
|Publisher:||Nature Publishing Group|
|Citations:||Web of Science®. Times cited: 109|
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