Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23771
Baumann, C R; Bassetti, C L; Valko, P O; Haybaeck, J; Keller, M; Clark, E; Stocker, R; Tolnay, M; Scammell, T E (2009). Loss of hypocretin (orexin) neurons with traumatic brain injury. Annals of Neurology, 66(4):555-559.
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Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the hypothalamic neurons that produce the wake-promoting neuropeptide hypocretin (orexin) causes the severe sleepiness of narcolepsy, and partial loss of these cells may contribute to the sleepiness of Parkinson disease and other disorders. We have found that the number of hypocretin neurons is significantly reduced in patients with severe TBI. This observation highlights the often overlooked hypothalamic injury in TBI and provides new insights into the causes of chronic sleepiness in patients with TBI.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||09 Nov 2009 16:52|
|Last Modified:||28 Nov 2013 02:15|
|Citations:||Web of Science®. Times Cited: 37|
Scopus®. Citation Count: 41
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