Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-238
Stemple, D L; Solnica-Krezel, L; Zwartkruis, F J T; Neuhauss, S C F; Schier, A F; Malicki, J; Stainier, D Y; Abdelilah, S; Rangini, Z; Mountcastle-Shah, E; Driever, W (1996). Mutations affecting development of the notochord in zebrafish. Development, 123:117-128.
The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.
134 downloads since deposited on 11 Feb 2008
15 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||1 December 1996|
|Deposited On:||11 Feb 2008 12:13|
|Last Modified:||05 Apr 2016 12:13|
|Publisher:||Company of Biologists|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page