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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-238

Stemple, D L; Solnica-Krezel, L; Zwartkruis, F J T; Neuhauss, S C F; Schier, A F; Malicki, J; Stainier, D Y; Abdelilah, S; Rangini, Z; Mountcastle-Shah, E; Driever, W (1996). Mutations affecting development of the notochord in zebrafish. Development, 123:117-128.

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Abstract

The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.

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134 citations in Web of Science®
122 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:1 December 1996
Deposited On:11 Feb 2008 12:13
Last Modified:27 Nov 2013 20:54
Publisher:Company of Biologists
ISSN:0950-1991
PubMed ID:9007234

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