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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23936

Kurzwelly, D; Glas, M; Roth, P; Weimann, E; Lohner, H; Waha, A; Schabet, M; Reifenberger, G; Weller, M; Herrlinger, U (2010). Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status. Journal of Neuro-Oncology, 97(3):389-392.

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Abstract

This retrospective series explores temozolomide monotherapy in elderly patients with primary CNS lymphoma (PCNSL) and severe comorbidities. In 17 patients (62-90 years old), the complete response rate was 47%, median progression-free survival was 5 months, and median overall survival was 21 months. Five of 17 patients (29.4%) had prolonged responses for at least 12 months and survived for more than 24 months. Three of these patients had a methylated O(6)-methylguanine-DNA methyltransferase (MGMT) promoter, while the MGMT status was not assessable in the remaining two patients. Temozolomide monotherapy appears to be effective in a subgroup of elderly PCNSL patients and deserves further evaluation.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:May 2010
Deposited On:12 Nov 2009 09:32
Last Modified:27 Nov 2013 17:32
Publisher:Springer
ISSN:0167-594X
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s11060-009-0032-0
PubMed ID:19841864
Citations:Web of Science®. Times Cited: 17
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Scopus®. Citation Count: 22

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