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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23946

Rasch, B; Spalek, K; Buholzer, S; Luechinger, R; Boesiger, P; Papassotiropoulos, A; de Quervain, D (2009). A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(45):19191-19196.

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Abstract

Emotionally arousing events are typically well remembered, but there is a large interindividual variability for this phenomenon. We have recently shown that a functional deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor, is related to enhanced emotional memory in healthy humans and enhanced traumatic memory in war victims. Here, we investigated the neural mechanisms of this effect in healthy participants by using fMRI. Carriers of the ADRA2B deletion variant exhibited increased activation of the amygdala during encoding of photographs with negative emotional valence compared with noncarriers of the deletion. Additionally, functional connectivity between amygdala and insula was significantly stronger in deletion carriers. The present findings indicate that the ADRA2B deletion variant is related to increased responsivity and connectivity of brain regions implicated in emotional memory.

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50 citations in Web of Science®
60 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
04 Faculty of Medicine > Institute of Biomedical Engineering
04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
170 Ethics
610 Medicine & health
Language:English
Date:10 November 2009
Deposited On:18 Nov 2009 13:35
Last Modified:27 Nov 2013 23:50
Publisher:National Academy of Sciences
ISSN:0027-8424
Additional Information:Copyright: National Academy of Sciences USA
Publisher DOI:10.1073/pnas.0907425106
PubMed ID:19826083

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