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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23995

Rohrer Bley, Carla; Laluhova, Dagmar; Roos, Malgorzata; Kaser-Hotz, Barbara; Ohlerth, Stefanie (2009). Correlation of pretreatment polarographically measured oxygen pressures with quantified contrast-enhanced power doppler ultrasonography in spontaneous canine tumors and their impact on outcome after radiation therapy. Strahlentherapie und Onkologie, 185(11):756-762.

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Purpose: To evaluate the use of noninvasive quantified contrast-enhanced power Doppler ultrasonography as a surrogate in the
estimation of tumor hypoxia measured by invasive pO2 histography in canine tumors.
Material and Methods: Data of pretreatment tumor oxygenation status, tumor vascularity and blood volume, and tumor response
after radiation therapy was collected in 48 spontaneous malignant oral tumors (Table 1). Tumor oxygenation status was
correlated to vascularity and blood volume, and influences on outcome after treatment were analyzed.
Results: Although vascularity and blood volume correlated moderately with median pO2 (r = 0.51 and 0.61; p = 0.001 and
< 0.0001) and percentage of pO2 readings ≤ 2.5, 5, and 10 mmHg (r = –0.37 to –0.42; p < 0.01–0.03) for all tumors, they did not
correlate within the different histology groups (p = 0.06–0.9). For all tumors, pretreatment oxygenation status, vascularity and
blood volume were not found to be of prognostic value (Tables 2 and 3).
Conclusion: These analyses show that quantified contrast-enhanced power Doppler ultrasonography does not represent a noninvasive
indirect method to assess tumor hypoxia measured by invasive pO2 histography. Both technologies were nonprognostic
indicators in spontaneous malignant canine oral tumors.


4 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:610 Medicine & health
Date:November 2009
Deposited On:26 Nov 2009 14:40
Last Modified:05 Apr 2016 13:33
Publisher DOI:10.1007/s00066-009-1988-6

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