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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-23998

Rohrer Bley, Carla; Wergin, Melanie; Roos, Malgorzata; Grenacher, Beat; Kaser-Hotz, Barbara (2007). Interrelation of directly measured oxygenation levels, erythropoietin and erythropoietin receptor expression in spontaneous canine tumours. European Journal of Cancer, 43(5):963-967.

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The expression of the hypoxia-inducible protein erythropoietin in tumour cells correlates with levels of tumour hypoxia. Our aim was to look for an interrelation of directly measured oxygenation levels, the presence of tissue erythropoietin and its receptor. Data of tumour oxygenation status, plasma and tissue erythropoietin and its receptor in a group of spontaneously occurring tumours in 15 dogs were collected. Polarographic tumour oxygen partial pressure measurements were obtained and data were correlated. Significant positive correlations were found between tissue erythropoietin and the percentages of pO2 values 610 mmHg. Multivariate analysis revealed no parameters influencing plasma erythropoietin levels. Our results show that a co-expression of erythropoietin receptor and its ligand in spontaneous canine tumours exists, that the level of hypoxia in tumour cells correlates with the level of tissue erythropoietin and suggest the need to be quantitatively and functionally tested as novel prognostic biological parameters in neoplastic tissues.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemology, Biostatistics and Prevention Institute (EBPI)
05 Vetsuisse Faculty > Institute of Veterinary Physiology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Division of Radiation Oncology
DDC:570 Life sciences; biology
610 Medicine & health
Date:March 2007
Deposited On:26 Nov 2009 14:53
Last Modified:27 Nov 2013 17:03
Publisher DOI:10.1016/j.ejca.2006.12.007
Citations:Web of Science®. Times Cited: 2
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Scopus®. Citation Count: 2

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