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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-24002

Rohrer Bley, Carla; Roos, Malgorzata; Price, Jill; Ruess-Melzer, Katja; Buchholz, Julia; Poirier, Valerie; Kaser-Hotz, Barbara (2007). Clinical assessment of repeated propofol-associated anesthesia in cats. Journal of the American Veterinary Medical Association, 231(9):1347-1353.

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Objective—To assess the effects of repeated episodes of propofol-associated anesthesia on quality of recovery from anesthesia, clinical status, and erythrocyte physiology in cats. Design—Original study. Animals—37 cats undergoing short-duration anesthesia for radiotherapy.
Procedures—Twice daily on 5 consecutive days, 13 cats with squamous cell carcinoma of the nasal planum (group 1) underwent anesthesia: first via administration of propofol or a midazolam (0.2 mg/kg [0.09 mg/lb])-propofol combination and then via administration of ketamine and midazolam each day (latter data were not analyzed). During a 19-day period, 24 cats with vaccineassociated sarcoma (group 2) were anesthetized 12 times with propofol or a midazolam-propofol combination. Anesthesia was maintained with propofol in both groups. Hematologic analysis was performed before, during, and on completion of radiotherapy; changes in Hct and hemoglobin concentration between groups were compared.
Results—Mean duration of anesthesia was 8.1 minutes (range, 5 to 20 minutes); no adverse events were detected during recovery. Total dose of propofol administered did not differ between groups 1 (6.34 mg/kg [2.88 mg/lb]) and 2 (4.71 mg/kg [2.14 mg/lb]). Midazolam administration decreased the propofol dose by 26%. Overall decreases from baseline in Hct and hemoglobin concentration were not significantly different between the 2 groups, nor clinically important; however, compared with baseline, values in group 2 were significantly lower after 6 and 12 anesthetic episodes for both protocols. Heinz bodies were identified in low numbers in both groups during radiotherapy.
Conclusions and Clinical Relevance—Results indicated that repeated propofol-associated short-duration anesthesia does not lead to clinically relevant hematologic changes in cats undergoing short-duration radiotherapy.


9 citations in Web of Science®
17 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:610 Medicine & health
Date:1 November 2007
Deposited On:27 Nov 2009 05:27
Last Modified:05 Apr 2016 13:33
Publisher:American Veterinary Medical Association
Publisher DOI:10.2460/javma.231.9.1347

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