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MyocardialT2*mapping free of distortion using susceptibility-weighted fast spin-echo imaging: A feasibility study at 1.5 T and 3.0 T


Heinrichs, U; Utting, J F; Frauenrath, T; Hezel, F; Krombach, G A; Hodenius, M A; Kozerke, S; Niendorf, T (2009). MyocardialT2*mapping free of distortion using susceptibility-weighted fast spin-echo imaging: A feasibility study at 1.5 T and 3.0 T. Magnetic Resonance in Medicine, 62(3):822-828.

Abstract

This study demonstrates the feasibility of applying free-breathing, cardiac-gated, susceptibility-weighted fast spin-echo imaging together with black blood preparation and navigator-gated respiratory motion compensation for anatomically accurate T2* mapping of the heart. First, T2* maps are presented for oil phantoms without and with respiratory motion emulation T2* = (22.1 +/- 1.7) ms at 1.5 T and T2* = (22.65 +/- 0.89) ms at 3.0 T). T2* relaxometry of a ferrofluid revealed relaxivities of R2* = (477.9 +/- 17) mM(-1)s(-1) and R2* = (449.6 +/- 13) mM(-1)s(-1) for UFLARE and multiecho gradient-echo imaging at 1.5 T. For inferoseptal myocardial regions mean T2* values of 29.9 +/- 6.6 ms (1.5 T) and 22.3 +/- 4.8 ms (3.0 T) were estimated. For posterior myocardial areas close to the vena cava T2*-values of 24.0 +/- 6.4 ms (1.5 T) and 15.4 +/- 1.8 ms (3.0 T) were observed. The merits and limitations of the proposed approach are discussed and its implications for cardiac and vascular T2*-mapping are considered.

This study demonstrates the feasibility of applying free-breathing, cardiac-gated, susceptibility-weighted fast spin-echo imaging together with black blood preparation and navigator-gated respiratory motion compensation for anatomically accurate T2* mapping of the heart. First, T2* maps are presented for oil phantoms without and with respiratory motion emulation T2* = (22.1 +/- 1.7) ms at 1.5 T and T2* = (22.65 +/- 0.89) ms at 3.0 T). T2* relaxometry of a ferrofluid revealed relaxivities of R2* = (477.9 +/- 17) mM(-1)s(-1) and R2* = (449.6 +/- 13) mM(-1)s(-1) for UFLARE and multiecho gradient-echo imaging at 1.5 T. For inferoseptal myocardial regions mean T2* values of 29.9 +/- 6.6 ms (1.5 T) and 22.3 +/- 4.8 ms (3.0 T) were estimated. For posterior myocardial areas close to the vena cava T2*-values of 24.0 +/- 6.4 ms (1.5 T) and 15.4 +/- 1.8 ms (3.0 T) were observed. The merits and limitations of the proposed approach are discussed and its implications for cardiac and vascular T2*-mapping are considered.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2009
Deposited On:18 Nov 2009 15:57
Last Modified:05 Apr 2016 13:33
Publisher:Wiley-Blackwell
ISSN:0740-3194
Publisher DOI:10.1002/mrm.22054
PubMed ID:19526490
Permanent URL: http://doi.org/10.5167/uzh-24039

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