Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-24041

Utting, J F; Kozerke, S; Luechinger, R; Schnitker, R; Vohn, R; Bhanniny, R; Tilbian, M; Niendorf, T (2009). Feasibility of k-t BLAST for BOLD fMRI with a spin-echo based acquisition at 3 T and 7 T. Investigative Radiology, 44(9):495-502.

[img] PDF - Registered users only
3MB

View at publisher

Abstract

OBJECTIVES: This study tested the feasibility of applying k-t BLAST to blood oxygen level dependent functional MRI of the brain at 3 Tesla (T) and at 7 T. Shorter echo train lengths, achieved through the application of k-t BLAST, are expected to counteract increased sensitivity to inhomogeneities in B0 at higher magnetic field strengths, especially in echo planar images, and reduce the relatively long acquisition times and high RF power deposition in spin-echo based methods. MATERIALS AND METHODS: k-t BLAST was combined with displaced UFLARE at 3 T and 7 T. Temporal and spatial fidelity of k-t BLAST were investigated using a test object, in which localized variations in signal intensity mimic activation-induced signal changes. fMRI was performed using typical box-car design finger tapping. In a separate analysis full k-space data were decimated to simulate k-t BLAST acquisitions and compare results with the fully sampled data, thereby avoiding physiological and noise differences between acquisitions. RESULTS: Activation can be detected at under-sampling factors as high as 16, whereas appropriately reconstructed data, under-sampled at factors below 8 entail insignificant loss of sensitivity and considerable reductions in acquisition times and RF power deposition. CONCLUSIONS: k-t BLAST is compatible with fMRI acquisitions and opens up possibilities including distortion-free T2*-weighted blood oxygen level dependent fMRI with displaced UFLARE at high magnetic field strengths.

Citations

Altmetrics

Downloads

1 download since deposited on 18 Nov 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:170 Ethics
610 Medicine & health
Language:English
Date:2009
Deposited On:18 Nov 2009 13:24
Last Modified:09 Jul 2012 04:00
Publisher:Lippincott Wiliams & Wilkins
ISSN:0020-9996
Publisher DOI:10.1097/RLI.0b013e3181b4c070
PubMed ID:19652607

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page