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Myc's secret life without Max


Gallant, P; Steiger, D (2009). Myc's secret life without Max. Cell Cycle, 8(23):3848-3853.

Abstract

The Myc transcription factors are amongst the most potent human oncoproteins, and they fulfill essential functions during normal development. Myc heterodimerizes with a protein called Max, and it has been widely assumed that all of Myc's activities depend on this association with Max. Recent evidence calls this view into question, as Myc proteins have been shown to retain considerable biological activity when not bound to Max. The molecular nature of this Max-independent Myc activity is likely to be manifold; one aspect we have recently found not to require Max is Myc's ability to activate RNA polymerase III-dependent transcription. The discovery of these Max-independent functions changes our understanding of basic Myc biology and it may affect pharmaceutical approaches to inhibiting Myc activity.

The Myc transcription factors are amongst the most potent human oncoproteins, and they fulfill essential functions during normal development. Myc heterodimerizes with a protein called Max, and it has been widely assumed that all of Myc's activities depend on this association with Max. Recent evidence calls this view into question, as Myc proteins have been shown to retain considerable biological activity when not bound to Max. The molecular nature of this Max-independent Myc activity is likely to be manifold; one aspect we have recently found not to require Max is Myc's ability to activate RNA polymerase III-dependent transcription. The discovery of these Max-independent functions changes our understanding of basic Myc biology and it may affect pharmaceutical approaches to inhibiting Myc activity.

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25 citations in Web of Science®
26 citations in Scopus®
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Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Uncontrolled Keywords:Drosophila, genetics, molecular biology, transcription, RNA polymerase III, growth, proliferation, apoptosis, competition, cancer, oncogene, tumor, transformation
Language:English
Date:1 December 2009
Deposited On:07 Dec 2009 12:11
Last Modified:05 Apr 2016 13:33
Publisher:Landes Bioscience
ISSN:1551-4005
Publisher DOI:https://doi.org/10.4161/cc.8.23.10088
Official URL:http://www.landesbioscience.com/journals/cc/article/10088/
PubMed ID:19887915
Permanent URL: https://doi.org/10.5167/uzh-24223

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