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In vitro heart valve tissue engineering


Schmidt, D; Mol, A; Kelm, J M; Hoerstrup, S P (2007). In vitro heart valve tissue engineering. In: Tissue Engineering. Springer: Humana Press, 319-330.

Abstract

Heart valve replacement represents the most common surgical therapy for end-stage valvular heart diseases. A major drawback all contemporary heart valve replacements have in common is the lack of growth, repair, and remodeling capabilities. To overcome these limitations, the emerging field of tissue engineering is focusing on the in vitro generation of functional, living heart valve replacements. The basic approach uses starter matrices of either decellularized xenogeneic or biopolymeric materials configured in the shape of the heart valve and subsequent cell seeding. Moreover, in vitro strategies using mechanical loading in bioreactor systems have been developed to improve tissue maturation. This chapter gives a short overview of the current concepts and provides detailed methods for in vitro heart valve tissue engineering.

Heart valve replacement represents the most common surgical therapy for end-stage valvular heart diseases. A major drawback all contemporary heart valve replacements have in common is the lack of growth, repair, and remodeling capabilities. To overcome these limitations, the emerging field of tissue engineering is focusing on the in vitro generation of functional, living heart valve replacements. The basic approach uses starter matrices of either decellularized xenogeneic or biopolymeric materials configured in the shape of the heart valve and subsequent cell seeding. Moreover, in vitro strategies using mechanical loading in bioreactor systems have been developed to improve tissue maturation. This chapter gives a short overview of the current concepts and provides detailed methods for in vitro heart valve tissue engineering.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2007
Deposited On:08 Dec 2009 13:35
Last Modified:05 Apr 2016 13:34
Publisher:Humana Press
Series Name:Methods in Molecular Medicine
Number:140
ISSN:1543-1894 (P) 1940-6037 (E)
ISBN:978-1-58829-756-3 (P) 978-1-59745-443-8 (E)
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:https://doi.org/10.1007/978-1-59745-443-8_18
PubMed ID:18085217

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