Haerle, S K; Strobel, K; Hany, T F; Sidler, D; Stoeckli, S J (2010). (18)F-FDG-PET/CT versus panendoscopy for the detection of synchronous second primary tumors in patients with head and neck squamous cell carcinoma. Head and Neck, 32(3):319-325.
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BACKGROUND.: This study assesses the additional value of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography/CT ((18)F-FDG-PET/CT) with respect to synchronous primaries in patients undergoing panendoscopy for staging of head and neck squamous cell carcinoma. METHODS.: In all, 311 patients underwent both modalities. Cytology, histology, and/or clinical/imaging follow-up served as reference standard. RESULTS.: The prevalence of second primary tumors detected by panendoscopy was 4.5%, compared with 6.1% detected by (18)F-FDG-PET/CT. The sensitivity for panendoscopy was 74%, the specificity was 99.7%, the positive predictive value (PPV) was 93%, and the negative predictive value (NPV) was 98%. The sensitivity for (18)F-FDG-PET/CT was 100%, the specificity was 95.7%, the PPV was 59%, and the NPV was 100%. CONCLUSIONS.: (18)F-FDG-PET/CT is superior to panendoscopy. With a negative (18)F-FDG-PET/CT, the extent of endoscopy can be reduced to the area of the primary tumor. Due to the costs, (18)F-FDG-PET/CT is recommended only in advanced disease to assess potential distant disease. In early-stage cancer, panendoscopy is accurate enough to rule out secondary tumors. (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
|DDC:||610 Medicine & health|
|Date:||22 March 2010|
|Deposited On:||07 Dec 2009 08:19|
|Last Modified:||17 Jan 2014 14:13|
|Free access at:||Official URL. An embargo period may apply.|
|Citations:||Web of Science®. Times Cited: 16|
Scopus®. Citation Count: 24
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