Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-24545

Roembke, J; Floate, K D; Jochmann, R; Schaefer, M A; Puniamoorthy, N; Knaebe, S; Lehmhus, J; Rosenkranz, B; Scheffczyk, A; Schmidt, T; Sharples, A; Blanckenhorn, W U (2009). Lethal and sublethal toxic effects of a test chemical (ivermectin) on the Yellow Dung Fly Scathophaga stercoraria based on a standardized international ring test. Environmental Toxicology and Chemistry, 28(10):2117-2124.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

A standardized bioassay using the yellow dung fly, Scathophaga stercoraria L. (Diptera: Scathophagidae), was developed to test the lethal and sublethal toxicity of parasiticide residues in livestock dung. The repeatability of the bioassay was assessed for the parasiticide, ivermectin, in thirteen tests performed in seven laboratories in Germany, the UK, Switzerland and Canada. Test results had an acceptable range of heterogeneity. The calculated concentration at which 50% egg-adult mortality was observed (Effect Concentration (EC50) averaged 20.8 +/- 19.1 (Standard Deviation (SD)) microg ivermectin / kg fresh dung (range: 6.33 - 67.5). Mortality was not observed below an average calculated No Observable Effect Concentration (NOEC) of 8.1 +/- 7.7 microg / kg. However, prolonged developmental time, and in a subset of tests reduced body size, was observed above an average calculated NOEC of 0.8 +/- 0.8 microg / kg. An oviposition choice test revealed further that yellow dung fly females do not discriminate among dung of different ivermectin concentrations. We conclude that the yellow dung fly is suitably sensitive, and the methods sufficiently repeatable, to support use of this standardized bioassay by the international community in the registration of new veterinary pharmaceuticals.

Citations

17 citations in Web of Science®
19 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 17 Dec 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
DDC:570 Life sciences; biology
590 Animals (Zoology)
Date:October 2009
Deposited On:17 Dec 2009 12:50
Last Modified:23 Nov 2012 14:47
Publisher:Society of Environmental Toxicology and Chemistry
ISSN:0730-7268
Publisher DOI:10.1897/08-599.1
PubMed ID:19432504

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page