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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-248

Zou, Y; Stoeckli, E T; Chen, H; Tessier-Lavigne, M (2000). Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell, 102(3):363-375.

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Abstract

Commissural axons cross the nervous system midline and then turn to grow alongside it, neither recrossing nor projecting back into ventral regions. In Drosophila, the midline repellent Slit prevents recrossing: axons cross once because they are initially unresponsive to Slit, becoming responsive only upon crossing. We show that commissural axons in mammals similarly acquire responsiveness to a midline repellent activity upon crossing. Remarkably, they also become responsive to a repellent activity from ventral spinal cord, helping explain why they never reenter that region. Several Slit and Semaphorin proteins, expressed in midline and/or ventral tissues, mimic these repellent activities, and midline guidance defects are observed in mice lacking neuropilin-2, a Semaphorin receptor. Thus, Slit and Semaphorin repellents from midline and nonmidline tissues may help prevent crossing axons from reentering gray matter, squeezing them into surrounding fiber tracts.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:04 August 2000
Deposited On:11 Feb 2008 13:14
Last Modified:23 Nov 2012 16:37
Publisher:Elsevier
ISSN:0092-8674
Related URLs:http://www.cell.com/content/article/abstract?uid=PIIS0092867400000416
PubMed ID:10975526
Citations:Google Scholar™

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