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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-24826

Ohlerth, Stefanie; Rohrer Bley, Carla; Laluhová, Dagmar; Roos, Malgorzata; Kaser-Hotz, Barbara (2010). Assessment of changes in vascularity and blood volume in canine sarcomas and squamous cell carcinomas during fractionated radiation therapy using quantified contrast-enhanced power Doppler ultrasonography: a preliminary study. Veterinary Journal, 186(1):58-63.

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Radiation therapy does not only target tumour cells but also affects tumour vascularity. In the present study, changes in tumour vascularity and blood volume were investigated in five grade 1 oral fibrosarcomas, eight other sarcomas (non-oral soft tissue and bone sarcomas) and 12 squamous cell carcinomas in dogs during fractionated radiation therapy (total dose, 45–56 Gy). Contrast-enhanced power Doppler ultrasound was performed before fraction 1, 3, 6, 8, 10, 12, 14 and 15 or 16 (sarcomas) or 17 (squamous
cell carcinomas). Prior to treatment, median vascularity and blood volume were significantly higher in squamous cell carcinomas (P = 0.0005 and 0.001), whereas measurements did not differ between oral fibrosarcomas and other sarcomas (P = 0.88 and 0.999). During the course of radiation therapy, only small, non-significant changes in vascularity and blood volume were observed in all three tumour histology
groups (P = 0.08 and P = 0.213), whereas median tumour volume significantly decreased until the end of treatment (P = 0.04 for fibrosarcomas and other sarcomas, P = 0.008 for squamous cell carcinomas). It appeared that there was a proportional decrease in tumour volume, vascularity and blood volume. Doppler measurements did not predict progression free interval or survival in any of the three tumour groups(P = 0.06–0.86). However, the number of tumours investigated was small and therefore, the results can only be considered preliminary.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:610 Medicine & health
Date:8 July 2010
Deposited On:28 Dec 2009 12:13
Last Modified:05 Apr 2016 13:35
Publisher DOI:10.1016/j.tvjl.2009.07.006
PubMed ID:19692273

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