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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-24833

Kook, P; Kranjc, A; Dennler, M; Glaus, T M (2009). Pancreatitis associated with clomipramine administration in a dog. Journal of Small Animal Practice, 50(2):95-98.

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A three-year-old, male, entire, Yorkshire terrier was presented with peracute onset of abdominal pain and vomitus. Clinicopathological abnormalities included severely increased serum lipase activity, immeasurably high serum trypsin-like immunoreactivity and mild hypocalcaemia. Canine pancreatic lipase immunoreactivity (cPLI)
was intended to be measured, however, the sample got lost.
Ultrasonography revealed a hypoechoic pancreas with small
amounts of peripancreatic fluid and hyperechogenic mesentery. Acute pancreatitis (AP) was diagnosed and the dog recovered with appropriate therapy within 48 hours. Clomipramine, a selective serotonin reuptake inhibitor (SSRI) for alleviating signs of separation anxiety had been given for seven weeks. Two similar, albeit less severe, episodes associated with previous courses of clomipramine had occurred eight months earlier that responded to discontinuing clomipramine and supportive care. As SSRIs are associated with AP in human beings and no other trigger could be identified, we conclude that clomipramine should be considered as a potential cause when investigating causes for AP in susceptible breeds or other dogs presenting with compatible clinical signs.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Division of Diagnostic Imaging
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Clinic for Small Animal Internal Medicine
DDC:570 Life sciences; biology
630 Agriculture
Date:February 2009
Deposited On:28 Dec 2009 13:22
Last Modified:28 Nov 2013 01:12
Publisher DOI:10.1111/j.1748-5827.2008.00690.x
PubMed ID:19200265
Citations:Web of Science®. Times Cited: 2
Google Scholar™
Scopus®. Citation Count: 2

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