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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-249

Fitzli, D; Stoeckli, E T; Kunz, S; Siribour, K; Rader, C; Kunz, B; Kozlov, S V; Buchstaller, A; Lane, R P; Suter, D M; Dreyer, W J; Sonderegger, P (2000). A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons. Journal of Cell Biology, 149(4):951-968.

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Abstract

An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti-axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry

07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:15 May 2000
Deposited On:11 Feb 2008 12:14
Last Modified:27 Nov 2013 22:53
Publisher:Rockefeller University Press
ISSN:0021-9525
Free access at:Official URL. An embargo period may apply.
Publisher DOI:10.1083/jcb.149.4.951
Related URLs:http://www.jcb.org/cgi/content/full/149/4/951
PubMed ID:10811834
Citations:Web of Science®. Times Cited: 49
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Scopus®. Citation Count: 53

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