Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-250
Chen, H; Bagri, A; Zupicich, J A; Zou, Y; Stoeckli, E T; Pleasure, S J; Lowenstein, D H; Skarnes, W C; Chédotal, A; Tessier-Lavigne, M (2000). Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron, 25(1):43-56.
View at publisher
Neuropilin-1 and neuropilin-2 bind differentially to different class 3 semaphorins and are thought to provide the ligand-binding moieties in receptor complexes mediating repulsive responses to these semaphorins. Here, we have studied the function of neuropilin-2 through analysis of a neuropilin-2 mutant mouse, which is viable and fertile. Repulsive responses of sympathetic and hippocampal neurons to Sema3F but not to Sema3A are abolished in the mutant. Marked defects are observed in the development of several cranial nerves, in the initial central projections of spinal sensory axons, and in the anterior commissure, habenulo-interpeduncular tract, and the projections of hippocampal mossyfiber axons in the infrapyramidal bundle. Our results show that neuropilin-2 is an essential component of the Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS.
51 downloads since deposited on 11 Feb 2008
13 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||1 January 2000|
|Deposited On:||11 Feb 2008 12:14|
|Last Modified:||28 Nov 2013 00:39|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page