Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-252

Burstyn-Cohen, T; Tzarfaty, V; Frumkin, A; Feinstein, Y; Stoeckli, E T; Klar, A (1999). F-Spondin is required for accurate pathfinding of commissural axons at the floor plate. Neuron, 23(2):233-246.

[img]
Preview
PDF
591kB

View at publisher

Abstract

The commissural axons project toward and across the floor plate. They then turn into the longitudinal axis, extending along the contralateral side of the floor plate. F-spondin, a protein produced and secreted by the floor plate, promotes adhesion and neurite extension of commissural neurons in vitro. Injection of purified F-spondin protein into the lumen of the spinal cord of chicken embryos in ovo resulted in longitudinal turning of commissural axons before reaching the floor plate, whereas neutralizing antibody (Ab) injections caused lateral turning at the contralateral floor plate boundary. These combined in vitro and in vivo results suggest that F-spondin is required to prevent the lateral drifting of the commissural axons after having crossed the floor plate.

Citations

83 citations in Web of Science®
81 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

25 downloads since deposited on 11 Feb 2008
7 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:1 June 1999
Deposited On:11 Feb 2008 12:14
Last Modified:27 Nov 2013 23:48
Publisher:Elsevier
ISSN:0896-6273
Publisher DOI:10.1016/S0896-6273(00)80776-X
Related URLs:http://www.neuron.org/content/article/abstract?uid=PIIS089662730080776X
PubMed ID:10399931

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page