Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2525
Linscheid, P; Christ-Crain, M; Stoeckli, R; Reusch, C E; Lutz, T A; Müller, B; Keller, U (2008). Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss. Diabetes, Obesity and Metabolism, 10(2):1266-1270.
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Aim: To determine the changes in adiponectin multimers upon marked weight loss.
Methods: Plasma samples were obtained preoperatively and 3, 6, 12 and 24 months after surgery from 12 obese subjects undergoing weight loss–inducing bariatric surgery. Seven non-operated obese subjects served as controls. Plasma levels of adiponectin multimers were determined by protease digestion and Enzyme-Linked ImmunoSorbent Assay (ELISA) detection. In addition, adiponectin multimers were assessed by western blotting.
Results: In patients with weight loss after surgery but not in controls, total adiponectin and high molecular weight (HMW) adiponectin steadily increased during the observation period. Twenty-four months after surgery, the increase in total and HMW adiponectin was 2.2 ± 0.46 and 1.4 ± 0.3 μg/ml, respectively. In contrast, plasma concentrations of middle and low molecular weight adiponectin remained unchanged.
Conclusions: The increase in plasma adiponectin levels observed 24 months after bariatric surgery depended on continuous weight loss and was completely attributable to the HMW complex.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Veterinary Physiology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||20 May 2008|
|Deposited On:||06 Jun 2008 08:37|
|Last Modified:||30 Oct 2014 15:51|
|Additional Information:||The definitive version is available at www.blackwell-synergy.com|
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