UZH-Logo

Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss


Linscheid, P; Christ-Crain, M; Stoeckli, R; Reusch, C E; Lutz, T A; Müller, B; Keller, U (2008). Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss. Diabetes, Obesity and Metabolism, 10(2):1266-1270.

Abstract

Aim: To determine the changes in adiponectin multimers upon marked weight loss.

Methods: Plasma samples were obtained preoperatively and 3, 6, 12 and 24 months after surgery from 12 obese subjects undergoing weight loss–inducing bariatric surgery. Seven non-operated obese subjects served as controls. Plasma levels of adiponectin multimers were determined by protease digestion and Enzyme-Linked ImmunoSorbent Assay (ELISA) detection. In addition, adiponectin multimers were assessed by western blotting.

Results: In patients with weight loss after surgery but not in controls, total adiponectin and high molecular weight (HMW) adiponectin steadily increased during the observation period. Twenty-four months after surgery, the increase in total and HMW adiponectin was 2.2 ± 0.46 and 1.4 ± 0.3 μg/ml, respectively. In contrast, plasma concentrations of middle and low molecular weight adiponectin remained unchanged.

Conclusions: The increase in plasma adiponectin levels observed 24 months after bariatric surgery depended on continuous weight loss and was completely attributable to the HMW complex.

Aim: To determine the changes in adiponectin multimers upon marked weight loss.

Methods: Plasma samples were obtained preoperatively and 3, 6, 12 and 24 months after surgery from 12 obese subjects undergoing weight loss–inducing bariatric surgery. Seven non-operated obese subjects served as controls. Plasma levels of adiponectin multimers were determined by protease digestion and Enzyme-Linked ImmunoSorbent Assay (ELISA) detection. In addition, adiponectin multimers were assessed by western blotting.

Results: In patients with weight loss after surgery but not in controls, total adiponectin and high molecular weight (HMW) adiponectin steadily increased during the observation period. Twenty-four months after surgery, the increase in total and HMW adiponectin was 2.2 ± 0.46 and 1.4 ± 0.3 μg/ml, respectively. In contrast, plasma concentrations of middle and low molecular weight adiponectin remained unchanged.

Conclusions: The increase in plasma adiponectin levels observed 24 months after bariatric surgery depended on continuous weight loss and was completely attributable to the HMW complex.

Citations

15 citations in Web of Science®
16 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

78 downloads since deposited on 06 Jun 2008
17 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:20 May 2008
Deposited On:06 Jun 2008 08:37
Last Modified:05 Apr 2016 12:23
Publisher:Wiley-Blackwell
ISSN:1462-8902
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:10.1111/j.1463-1326.2008.00899.x
PubMed ID:18494809
Permanent URL: http://doi.org/10.5167/uzh-2525

Download

[img]
Preview
Content: Accepted Version
Filetype: PDF
Size: 1MB
View at publisher
[img]
Filetype: PDF - Registered users only
Size: 1MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations