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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2525

Linscheid, P; Christ-Crain, M; Stoeckli, R; Reusch, C E; Lutz, T A; Müller, B; Keller, U (2008). Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss. Diabetes, Obesity and Metabolism, 10(2):1266-1270.

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Abstract

Aim: To determine the changes in adiponectin multimers upon marked weight loss.

Methods: Plasma samples were obtained preoperatively and 3, 6, 12 and 24 months after surgery from 12 obese subjects undergoing weight loss–inducing bariatric surgery. Seven non-operated obese subjects served as controls. Plasma levels of adiponectin multimers were determined by protease digestion and Enzyme-Linked ImmunoSorbent Assay (ELISA) detection. In addition, adiponectin multimers were assessed by western blotting.

Results: In patients with weight loss after surgery but not in controls, total adiponectin and high molecular weight (HMW) adiponectin steadily increased during the observation period. Twenty-four months after surgery, the increase in total and HMW adiponectin was 2.2 ± 0.46 and 1.4 ± 0.3 μg/ml, respectively. In contrast, plasma concentrations of middle and low molecular weight adiponectin remained unchanged.

Conclusions: The increase in plasma adiponectin levels observed 24 months after bariatric surgery depended on continuous weight loss and was completely attributable to the HMW complex.

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15 citations in Web of Science®
16 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
DDC:570 Life sciences; biology
Language:English
Date:20 May 2008
Deposited On:06 Jun 2008 08:37
Last Modified:30 Oct 2014 15:51
Publisher:Wiley-Blackwell
ISSN:1462-8902
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:10.1111/j.1463-1326.2008.00899.x
PubMed ID:18494809

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