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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-25530

Hasler, F; Kuznetsova, O F; Krasikova, R N; Cservenyak, T; Quednow, B B; Vollenweider, F X; Ametamey, S M; Westera, G (2009). GMP-compliant radiosynthesis of [18F]altanserin and human plasma metabolite studies. Applied Radiation and Isotopes, 67(4):598-601.

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Abstract

[(18)F]altanserin is the preferred radiotracer for in-vivo labeling of serotonin 2A receptors by positron emission tomography (PET). We report a modified synthesis procedure suited for reliable production of multi-GBq amounts of [(18)F]altanserin useful for application in humans. We introduced thermal heating for drying of [(18)F]fluoride as well as for the reaction instead of microwave heating. We furthermore describe solid phase extraction and HPLC procedures for quantitative determination of [(18)F]altanserin and metabolites in plasma. The time course of arterial plasma activity with and without metabolite correction was determined. 90 min after bolus injection, 38.4% of total plasma activity derived from unchanged [(18)F]altanserin. Statistical comparison of kinetic profiles of [(18)F]altanserin metabolism in plasma samples collected in the course of two ongoing studies employing placebo, the serotonin releaser dexfenfluramine and the hallucinogen psilocybin, revealed the same tracer metabolism. We conclude that metabolite analysis for correction of individual plasma input functions used in tracer modeling is not necessary for [(18)F]altanserin studies involving psilocybin or dexfenfluramine treatment.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
DDC:610 Medicine & health
Language:English
Date:April 2009
Deposited On:15 Dec 2009 12:27
Last Modified:27 Nov 2013 23:40
Publisher:Elsevier
ISSN:0969-8043
Publisher DOI:10.1016/j.apradiso.2008.12.007
PubMed ID:19162492
Citations:Web of Science®. Times Cited: 5
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Scopus®. Citation Count: 7

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