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From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia


Maier, W; Mössner, R; Quednow, B B; Wagner, M; Hurlemann, R (2008). From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 258(Supp. 5):40-43.

Abstract

Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.

Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.

Citations

11 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:November 2008
Deposited On:06 Jan 2010 16:47
Last Modified:05 Apr 2016 13:37
Publisher:Springer
ISSN:0940-1334
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00406-008-5011-5
PubMed ID:18985293

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