Maier, W; Mössner, R; Quednow, B B; Wagner, M; Hurlemann, R (2008). From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 258(Supp. 5):40-43.
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Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics|
|DDC:||610 Medicine & health|
|Deposited On:||06 Jan 2010 16:47|
|Last Modified:||28 Nov 2013 00:45|
|Additional Information:||The original publication is available at www.springerlink.com|
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