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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-25571

Pleger, B; Ruff, Christian C; Blankenburg, F; Klöppel, S; Driver, J; Dolan, R J (2009). Influence of dopaminergically mediated reward on somatosensory decision-making. PLoS Biology, 7(7):e1000164.

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Abstract

Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being rewarded for correct performance at trial end via a visual signal, at one of four anticipated financial levels. Prior to the procedure, participants received either placebo (saline), a dopamine agonist (levodopa), or an antagonist (haloperidol). Principal findings: higher anticipated reward improved tactile decisions. Visually signalled reward reactivated primary somatosensory cortex for the judged hand, more strongly for higher reward. After receiving a higher reward on one trial, somatosensory activations and decisions were enhanced on the next trial. These behavioural and neural effects were all enhanced by levodopa and attenuated by haloperidol, indicating dopaminergic dependency. Dopaminergic reward-related influences extend even to early somatosensory cortex and sensory decision-making.

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33 citations in Web of Science®
38 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
DDC:170 Ethics
330 Economics
Language:English
Date:July 2009
Deposited On:14 Dec 2009 13:16
Last Modified:12 Nov 2014 12:25
Publisher:Public Library of Science (PLoS)
ISSN:1544-9173
Publisher DOI:10.1371/journal.pbio.1000164

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