Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-25731

Pichler Hefti, J; Risch, L; Hefti, U; Scharrer, I; Risch, G; Merz, T M; Turk, A; Bosch, M M; Barthelmes, D; Schoch, O; Maggiorini, M; Huber, A R (2010). Changes of coagulation parameters during high altitude expedition. Swiss Medical Weekly, 140(7-8):111-117.

[img]
Preview
PDF
1MB

Abstract

PRINCIPLES: Data on changes of haemostatic parameters at altitudes above 5000 m are very limited. So far it is unknown, whether altered coagulation could contribute to the development of acute mountain sickness. METHODS: Thirty four healthy mountaineers were randomised to two acclimatisation protocols and undertook an expedition on Muztagh Ata (7549 m) in China. Tests were performed at five altitudes up to 6865m. Haemostatic parameters, such as PT, aPTT, D-Dimer, APC-Resistance (APCR), von Willebrand Factor activity (RCo), ADAMTS-13 & C-Natriuretic Peptide (CNP) were assessed together with Lake Louise AMS score. RESULTS: D-Dimer significantly increased with increasing altitude (median 0.62 to 0.81 mg/L, p <0.0001). During ascent, PT increased (83% to >100%) and APCR decreased significantly from 0.95 to 0.8 (p <0.01). Furthermore, a significant increase of aPTT (38 to 43 sec) was paralleled by significant changes of RCo (102% to 62%) (both p <0.001). There were no significant changes in ADAMTS-13 and CNP. No significant relationship between investigated parameters and AMS scores could be detected. When comparing the participants of the two acclimatisation protocols, there was an overall higher RCo in patients with a faster ascent protocol (p = 0.04). This was accompanied by lower ADAMTS-13 of the coagulation system in these patients (p = 0.04). CONCLUSIONS: Coagulation parameters change significantly during hypobaric hypoxia. Whereas we could detect no association between AMS scores and coagulation parameters, our results do show some parameters to be associated with an acclimatisation protocol and a successful ascent to the summit.

Citations

Downloads

209 downloads since deposited on 16 Dec 2009
113 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:16 Dec 2009 09:57
Last Modified:20 Jul 2014 18:47
Publisher:EMH Swiss Medical Publishers
ISSN:0036-7672
Official URL:http://www.smw.ch/docs/PdfContent/smw-12910.pdf
Related URLs:http://www.smw.ch/ (Publisher)
PubMed ID:19950043

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page